Jon Michael Moore Trauma Center
Research & Education
Research
The trauma center is committed to understanding injury, prevention and improving the management and treatment of trauma patients. Our faculty works with a multidisciplinary team to conduct research about reducing injury-related morbidity and mortality. We assist investigators in conducting trauma-related research at WVU. The information is frequently used to develop public health policies.
Morphine/Ketamine PCA Study
- This is a randomized study for patients suffering blunt chest wall trauma in whom a PCA will be given for pain.
- A total of 40 patients (20 in each arm) will be enrolled using an even odd day randomization scheme.
- The main objective of this study is to see if a low dose of Ketamine combined with Morphine will relieve blunt chest wall trauma pain and also improve lung status.
- Inclusion Criteria:
- All patients > age 18 with chest wall trauma and/or rib fractures admitted to the ICU or step down unit and requiring PCA following the rib fracture protocol.
Rib Fracture Protocol
Exclusion Criteria:
- Age <18
- Systolic BP > 180
- Heart Rate > 130
- Pts. with documented TBI on CT scan with evidence of increased ICP
- Orbital injury with evidence of increased IOP
- History of Glaucoma
- History of major psychiatric disorder, i.e. schizophrenia and/or visual/auditory hallucinations
- History of significant cardiac disease, i.e. previous CABG or major valvular heart disease
- Allergy to either Morphine or Ketamine
- Inability to use a PCA
Randomization:
- Even Days: Standard Morphine PCA
- Odd Days: Morphine/Ketamine
To Order:
- Select Drug Study function in CHIP ordering functions, click on Morphine/Ketamine study - select either morphine alone or morphine/ketamine and follow screens
Remember:
- Informed consent must be obtained prior to enrollment.
- Study participation ends when either the PCA is discontinued or the patient is transferred to the floor.
Questions? Call Jane Channel at 75079
- Morphine will also be used as the standard rescue medication.
**Additional Instructions/Helpful Hints
- Have patient initial and date each page.
- Please explain and read consent to pt. Ask if any questions.
- Give pt. a copy of consent and HIPAA form. Original goes in chart.
- Get initial FVC before starting PCA- as per rib fracture protocol.
- Ketamine dose will be 1.5 mg to 2 mg Morphine- this needs typed in - with lockout of 8 minutes.
- Consent needs witness signature.
- Please be sure to order the rescue pain med as part of CHIP order (it is there for both arms).
