Christopher P. Cifarelli, M.D., Ph.D., Director of the WVU Medicine Gamma Knife program and member of the WVU Cancer Institute Research Programs, presented a talk on his team’s research during the 2018 ISIORT conference in Mannheim, Germany. Dr. Cifarelli presented two sessions: Feasibility of Dose Escalation Using Intraoperative Radiotherapy Following Resection of Large Brain Metastases Compared to Post-operative SRS and Neurosurgical Nuances of IORT for Intracranial Lesions. The work focuses on a novel use of radiation delivered to the brain at the time of surgery as a means to decrease long-term radiation doses and improve overall outcomes for patients with metastatic and primary brain tumors. The conference had about 300 specialists from over 20 nations in attendance. Dr. Cifarelli is a faculty member in the WVU Department of Neurosurgery and a member of the Radiation Oncology team at WVU Cancer Institute. This work was co-authored by Joshua Hack MS, Geraldine M. Jacobson MD, and J. Austin Vargo MD.